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Elastic properties of force-transmitting linkages determine multistable mechanosensitive behaviour of cell adhesion

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Nature Physics, Published online: 18 July 2025; doi:10.1038/s41567-025-02964-z

The cytoskeleton and extracellular matrix are linked by molecular clutches that enable cells to sense their environment. Now it is shown that the elastic properties of the clutches underpin stiffness sensing.