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Three-dimensional cell morphology is mediated by curvature sensing and interfacial stress

Submitted by wwwadm on

Nature Physics, Published online: 26 October 2026; doi:10.1038/s41567-026-03482-2

Cells adhering to micro-curved surfaces can exhibit either complete adhesion or partial interior detachment. This is now found to be determined by the balance between the cell contractile stress and the cell–substrate adhesion stress.